Abstract:
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease of the joints in children, characterized
by autoimmune damage to connective tissue and systemic manifestations. Among extra-articular lesions,
particular importance is attached to the involvement of the urinary system, which significantly affects the course,
prognosis, and treatment strategy of the disease.
Objective: To study the clinical and immunological changes in the urinary system in children with juvenile
idiopathic arthritis.
Materials and Methods: A total of 80 patients aged 4–17 years were examined. All patients underwent clinical,
laboratory, and immunological studies.
Results: Urinary system involvement was detected in 66 (82.5%) children, manifested by leukocyturia (79%),
proteinuria (52%), hematuria (35%), and the presence of salts in the urine (32%). Serum IL-6 levels were elevated
5.8-fold, particularly in polyarticular and systemic forms of the disease.
