Abstract:
Non-alcoholic fatty liver disease (NAFLD) is now characterized as the hepatic
manifestation of metabolic syndrome, is the leading cause of liver cirrhosis and currently affects
a quarter of the world's population. A number of recent studies have focused on the prevalence of
neurodegeneration, including dementia and cognitive impairment in NAFLD. Various risk
factors, including insulin resistance, cerebrovascular dysfunction, intestinal dysbiosis,
hyperammonemia, neuroinflammation and etc. Given the prevalence of NAFLD, its negative
impact on cognitive function is a medical problem with enormous social and economic
consequences. This article reviews the available evidence for the role of NAFLD in the
development of neurodegeneration and describes possible mechanisms involved in the
development of brain dysfunction in NAFLD.
