FEATURES OF PUBERTAL DEVELOPMENT IN GIRLS WITH SIGNS OF UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA: CLINICAL, HORMONAL AND ULTRASOUND ANALYSIS

Abstract

Undifferentiated connective tissue dysplasia (UCTD) is a common polygenic condition associated with structural and functional changes in collagen and extracellular matrix synthesis. In adolescent girls, UCTD may influence the timing and quality of pubertal development, menstrual function, and reproductive organ formation. Despite its frequency, UCTD often remains underdiagnosed and is rarely considered as a risk factor for hormonal imbalance in puberty.