Abstract:
Objective: To investigate carbohydrate metabolism parameters in patients with
metabolic dysfunction–associated fatty liver disease (MAFLD) depending on the presence of renal
dysfunction. The study assessed kidney functional status in young patients with metabolic
dysfunction–associated fatty liver disease (MAFLD). A total of 105 patients aged 18–45 years with
ultrasound-confirmed hepatic steatosis were included and divided into two groups: MAFLD (n =
81) and MAFLD + chronic kidney disease (CKD) (n = 24). Patients with MAFLD and renal
dysfunction demonstrated significantly higher levels of fasting glucose, insulin, HbA1c, and
metabolic indices—HOMA-IR, TyG, and METS-IR—compared with MAFLD patients without
renal impairment. The integral indices of insulin resistance showed significant correlations with
eGFR and albuminuria: HOMA-IR, TyG, and METS-IR were inversely associated with eGFR and
positively associated with the albumin-to-creatinine ratio (A/Cr). Young patients with concomitant
MAFLD and CKD exhibit a marked exacerbation of metabolic disturbances, including increases
in HOMA-IR, TyG, and METS-IR, indicating more pronounced insulin resistance. Integral insulin
resistance indices—HOMA-IR, TyG, and METS-IR—demonstrate significant correlations with
eGFR and albuminuria.
