Abstract:
This study aimed to analyze maternal outcomes in pregnant women infected
with COVID-19, focusing on the impact of disease severity, timing of medical
intervention, and the effect of different SARS-CoV-2 variants. A retrospective
analysis was conducted on 9,288 pregnant women diagnosed with COVID-19.
Disease severity was classified as mild (30%), moderate (52%), severe (17%),
and critical (2%). The study also examined the timing of medical care, with
41.6% of women seeking care within 7 days of symptom onset and 58.4% after
7 days. The average gestational age was 271.8 days, with the majority (93.8%)
at full-term pregnancy. Results indicated that 88.2% of women continued their
pregnancies during treatment, while 11.9% experienced pregnancy termina tion, including preterm deliveries and miscarriages. The study found a signif icant (p < 0.05) association between COVID-19 severity and adverse out comes, such as preterm birth and maternal mortality. Severe and critical cases
demonstrated increased risks of uteroplacental insufficiency (52.1% and
85.5%, respectively), the need for intensive respiratory support, and ICU ad mission. The differences in outcomes between the Delta and Omicron vari ants. The Delta variant was associated with more severe disease and higher
rates of complications, including a higher need for cesarean sections, com pared to the Omicron variant. The overall 30-day survival rate was 98.05%,
with a noticeable drop to 43.59% in critically ill patients. This study under scores the importance of early medical intervention and continuous monitor ing in managing COVID-19 in pregnant women. The findings also emphasize
the need to consider the variant-specific effects of SARS-CoV-2 on maternal
and neonatal outcomes, which can guide clinical decision-making and im prove the prognosis for both mother and child
