Abstract:
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation and systemic inflammation. Growing evidence suggests a link between gut
microbiota alterations and metabolic dysregulation in COPD.
Methods: A cross-sectional study included 20 COPD patients (mean age: 65.4 ± 8.3 years,
57% male). Pulmonary function was assessed using FEV₁, FEV₁/FVC, and residual volume. Gut microbiota composition was analyzed via 16S rRNA sequencing, and plasma citrulline
and glycine levels were measured using LC-MS. Correlation analysis examined associations
between lung function, microbiota composition, and amino acid metabolism.
