Abstract:
In order to identify the key clinical and anamnestic factors of deterioration in the quality of life (QOL)
of cardiac patients depending on the destabilization of the atherosclerotic process, 152 patients of both sexes with a
verified diagnosis of coronary heart disease were studied. The subjects were divided into two groups: the main group
- 73 patients with coronary heart disease, Unstable angina (UA) and the comparison group - 79 patients diagnosed
with coronary heart disease, stable angina pectoris (SAP) of III functional classes (FC). Among the studied patients,
a questionnaire was conducted to assess QOL using the international questionnaire EQ-5D and the visual analog scale
EQ-VAS, followed by an assessment of the impact of socio-demographic and clinical factors on QOL in patients with
coronary heart disease. During the study, it was revealed that the level of quality of life of patients with coronary heart
disease had significant differences in the compared groups depending on the progression of the clinical course. The
average values of the QOL components according to the EQ-5D questionnaire, such as self-care (EQ-2) (p=0.01), the
presence of pain/discomfort (EQ-4) (p=0.05) and anxiety/depression (EQ-4) (p=0.01), as well as the state of health
according to EQ-VAS in patients with SSN of the main group were significantly worse against the background of the
manifestation of the disease (p=0.01) in contrast to patients with SSN. Multivariate regression analysis found that
factors affecting QOL, such as female gender, old age, higher education, as well as cardiovascular risk factors (FR)
such as obesity, arterial hypertension (AH) and dyslipidemia had a significant negative impact on the values of the
EQ-5D index (p <0.05). Thus, the QOL level of patients with coronary heart disease had significantly low values of
the EQ-5D and EQ-VAS index with the Unstable angina, which is aggravated by the presence of factors such as female
gender, old age, higher education among demographic factors and obesity, hypertension and dyslipidemia among
clinical and laboratory factors
