Clinical predictors of gene polymorphism in the occurrence of hyperuricemia and gout

Abstract

The article presents modern data on the influence of the most common polymorphisms SLC2A9 and ABCG2 of genes encoding proteins that are involved in the renal urate transport system and, thus, associated with the level of uric acid or gout. Characterization of polymorphisms SLC2A9 and ABCG2 of genes: V253I, Q126X, Q141K was carried out. It was determined that the GCA and GTC haplotypes of the Q126X and Q141K polymorphisms can be predictors of gout. The interrelation of SLC2A9 and ABCG2 gene polymorphisms with the presence of hyperuricemia depending on gender, components of metabolic syndrome, and response to allopurinol was analyzed. Most genes associated with MK or gout in a genome-wide association study encode proteins that are involved in the renal urate transport system, for example, SLC2A9 (solute carrier family 2, member 9) and ABCG2 (ATP-binding cassette, family G) are well-known genes for urate transporters responsible for their reabsorption and excretion. Thus, the determination of polymorphism - SLC2A9 and ABCG2 genes can help in diagnosing the risk of developing gout and optimizing the schemes of uricosuric therapy in patients with refractory gout