Abstract:
Non-invasive prenatal testing (NIPT) has emerged as a
transformative tool in modern obstetric care, offering a highly
accurate and safe method for early detection of fetal genetic
anomalies. This article examines the evolution of NIPT,
highlighting its clinical applications, benefits, and limitations.
The integration of next-generation sequencing (NGS) and cellfree
fetal DNA (cffDNA) analysis has significantly enhanced
diagnostic accuracy, reducing the need for invasive procedures
like amniocentesis and chorionic villus sampling (CVS). While
NIPT is primarily used to detect chromosomal disorders such as
trisomy 21, 18, and 13, its potential applications extend to
broader genetic screening and prenatal disease management.
Ethical considerations, accessibility, and the economic impact of
implementing NIPT in diverse healthcare systems are also
explored. These advances underscore the pivotal role of NIPT in
improving maternal and fetal outcomes, paving the way for
personalized obstetric care.
