Abstract:
Cardiovascular autonomic neuropathy (CAN) is a severe and underdiagnosed
complication of diabetes mellitus, significantly increasing the risk of cardiovascular morbidity
and mortality. CAN results from damage to the autonomic nerves that control heart rate and
vascular function, leading to an array of symptoms, including resting tachycardia, orthostatic
hypotension, and silent myocardial ischemia. This article explores the pathophysiological
mechanisms underlying CAN, its clinical manifestations, diagnostic approaches, and the link
between CAN and the progression of other diabetes-related complications. Furthermore, it
highlights preventive and therapeutic strategies aimed at early detection and management of
CAN, emphasizing its role in reducing the overall burden of diabetes complications.
