CONDITION OF DYSLIPIDEMIA AND CYTOKINE PROFILE IN PATIENTS WITH GOUT: THE ROLE OF IL-6, IL-18 AND THE PLACE OF HYPERURICEMIA IN THE DEVELOPMENT OF METABOLIC DISORDERS

Abstract

Objective: to investigate the relationship between indexes of dyslipidemia and immunological changes in patients with tophaceous gout and asymptomatic hyperuricemia. Patients and methods. The study included 85 male patients: 1st group – 49 patients with primary chronic gout according to Wallace S.L. criteria, 2nd (control) group – 36 patients with asymptomatic hyperuricemia. The levels of uric acid (UA), C-reactive protein (CRP), fasting glycemia, lipid profile – total cholesterol (TC), triglycerides (TG), high-density (HDL), low density (LDL), very low density (VLDL) lipoproteins, atherogenic ratio (AR); cytokine concentrations: interleukin-1β (IL 1β), tumor necrosis factor-α (TNF-α), IL-4, IL-6, IL-8, IL-10 and IL-18 in the blood serum using enzyme-linked immunosorbent assay.