Abstract:
As a result of the study conducted, it was witnessed that the G allele and the
heterozygous A / G genotype of the IL17F gene (rs763780) among patients with RA are
significantly higher than in the control group. In particular, the most significant discrepancies
were registered in patients with articular-visceral form of the disease whom the G allele exceeded
the proportion of carriage in the control statistically significantly 2.58 times (χ2 = 4.512; P =
0.037; OR = 2.58; 95% CI: 1.076 -6.188). On the part of the heterozygous genotype A / G there
was a clear tendency to increase its frequency by more than twice (χ2 = 2.011; P = 0.165; OR =
2.068; 95% CI: 0758-5.645) which in turn indicates the possible participation of the studied
polymorphism in the pathogenesis of RA
