Association of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan

dc.contributor.author	M. Sh. Karimov, A. A. Eshmurzaeva, Kh. M. Marufkhanov & M. V. Sibirkina
dc.date.accessioned	2025-03-11T14:34:26Z
dc.date.available	2025-03-11T14:34:26Z
dc.date.issued	2021-11-27
dc.identifier.uri	http://repo.tma.uz/xmlui/handle/1/1050
dc.description.abstract	As a result of the study conducted, it was witnessed that the G allele and the heterozygous A / G genotype of the IL17F gene (rs763780) among patients with RA are significantly higher than in the control group. In particular, the most significant discrepancies were registered in patients with articular-visceral form of the disease whom the G allele exceeded the proportion of carriage in the control statistically significantly 2.58 times (χ2 = 4.512; P = 0.037; OR = 2.58; 95% CI: 1.076 -6.188). On the part of the heterozygous genotype A / G there was a clear tendency to increase its frequency by more than twice (χ2 = 2.011; P = 0.165; OR = 2.068; 95% CI: 0758-5.645) which in turn indicates the possible participation of the studied polymorphism in the pathogenesis of RA	en_US
dc.language.iso	en	en_US
dc.subject	rheumatoid arthritis (RA), rs763780 polymorphism of gene IL17F, carriage, allele, genotype, develoment risk.	en_US
dc.title	Association of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan	en_US
dc.type	Article	en_US