Abstract:
Atopic dermatitis is a multifactorial disease caused by the combined effects of genetic changes
and trigger mechanisms in the body. It is known that the etiopathogenetic «basis» of multifactorial
diseases is the creation of a certain polymorphic form of functionally defective genes (genetic
«predispositions», candidate genes, mediator genes) that have a detrimental effect on the environment.
Based on historical sources, atopic dermatitis is an «abnormal» genetically determined reaction of the
body to inhalation and food allergens, characterized by an increase in the amount of immunoglobulin
E (IgE) and specific IgE antibodies in response. In our current work, we will consider the origin of
atopic dermatitis and its relationship with other allergic diseases. Risk factors for comorbidity are
identified. Materials and methods of the study. The study included 130 children aged 6 to 12 years
with bronchial asthma and AtD, who underwent inpatient treatment at the multidisciplinary clinic of the
Tashkent Medical Academy in 2019-2024.
