RISK FACTORS AND CLINICAL FEATURES OF COMORBID ATOPIC DERMATITIS IN CHILDREN

Abstract

Atopic dermatitis is a multifactorial disease caused by the combined effects of genetic changes and trigger mechanisms in the body. It is known that the etiopathogenetic «basis» of multifactorial diseases is the creation of a certain polymorphic form of functionally defective genes (genetic «predispositions», candidate genes, mediator genes) that have a detrimental effect on the environment. Based on historical sources, atopic dermatitis is an «abnormal» genetically determined reaction of the body to inhalation and food allergens, characterized by an increase in the amount of immunoglobulin E (IgE) and specific IgE antibodies in response. In our current work, we will consider the origin of atopic dermatitis and its relationship with other allergic diseases. Risk factors for comorbidity are identified. Materials and methods of the study. The study included 130 children aged 6 to 12 years with bronchial asthma and AtD, who underwent inpatient treatment at the multidisciplinary clinic of the Tashkent Medical Academy in 2019-2024.