Abstract:
Acute lymphoblastic leukemia (ALL) in children is one of the most common malignant
disorders of the hematopoietic system. This study investigates the pathologoanatomical and
morphological features of ALL. Findings revealed diffuse infiltration of blast cells in the bone
marrow, lymph nodes, spleen, liver, and thymus. Histological analysis demonstrated high
proliferative activity of blasts and suppression of normal hematopoiesis. Immunohistochemical
results confirmed the expression of CD10, CD19, and TdT markers in B-ALL, while CD3 was
characteristic for T-ALL. The obtained data indicate the systemic nature of organ involvement in ALL
and highlight the importance of morphological examination in early diagnosis.
