Abstract:
To study the pathogenetic
mechanisms and clinical manifestations of
GERD in asthma and COPD. Methods: A study of
68 patients with GERD, asthma, and COPD;
diagnostics included impedance-pH monitoring,
spirometry, and analysis of inflammatory
markers (CRP, IL-6, IL-8). Results: Aspiration was
more frequent in COPD (60%) and asthma
(42%) patients. Elevated CRP, IL-6, IL-8 levels
and vagal reflex hyperactivity were associated
with bronchospasms. Conclusions: GERD
exacerbates respiratory symptoms, requiring a
comprehensive treatment approach.
