Abstract:
The prognostic relevance of intratumoral stromal mast cells (MCs) in renal cell carcinoma (RCC)
remains insufficiently investigated and controversial. The present study aimed to evaluate the
quantitative characteristics of stromal mast cells in RCC and to analyze their relationship with major
clinical, anatomical, and histopathological prognostic factors. Surgical specimens obtained from 63
patients with renal cell carcinoma were examined using histological and immunohistochemical
methods. Mast cells were identified by CD117 (c-Kit) expression and quantified in representative
high-power fields. The analysis demonstrated a significant association between increased mast cell
density and advanced tumor stage, aggressive histological variants, and the presence of metastatic
disease. These findings suggest that stromal mast cell infiltration may serve as an additional
prognostic indicator in renal cell carcinoma
