ANALYSIS OF MORPHOLOGICAL FEATURES AND PROGNOSTIC VALUE OF  INTRATUMORAL STROMAL MAST CELLS IN RENAL CELL CARCINOMA

Murod Matyakubovich Atakhonov

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dc.contributor.author	Murod Matyakubovich Atakhonov
dc.date.accessioned	2026-06-29T11:38:27Z
dc.date.available	2026-06-29T11:38:27Z
dc.date.issued	2026
dc.identifier.uri	http://repo.tma.uz/xmlui/handle/1/4664
dc.description.abstract	The prognostic relevance of intratumoral stromal mast cells (MCs) in renal cell carcinoma (RCC) remains insufficiently investigated and controversial. The present study aimed to evaluate the quantitative characteristics of stromal mast cells in RCC and to analyze their relationship with major clinical, anatomical, and histopathological prognostic factors. Surgical specimens obtained from 63 patients with renal cell carcinoma were examined using histological and immunohistochemical methods. Mast cells were identified by CD117 (c-Kit) expression and quantified in representative high-power fields. The analysis demonstrated a significant association between increased mast cell density and advanced tumor stage, aggressive histological variants, and the presence of metastatic disease. These findings suggest that stromal mast cell infiltration may serve as an additional prognostic indicator in renal cell carcinoma	en_US
dc.language.iso	en_US	en_US
dc.publisher	O'zbekiston "YANGI O‘ZBEKISTONDA TABIIY VA IJTIMOIY-GUMANITAR FANLAR" RESPUBLIKA ILMIY-AMALIY KONFERENSIYASI	en_US
dc.relation.ispartofseries	UDK;616.6;616-006
dc.subject	renal cell carcinoma, tumor microenvironment, stromal mast cells, prognosis	en_US
dc.title	ANALYSIS OF MORPHOLOGICAL FEATURES AND PROGNOSTIC VALUE OF INTRATUMORAL STROMAL MAST CELLS IN RENAL CELL CARCINOMA	en_US
dc.type	Article	en_US