Abstract:
Relevance of the topic: Failure of patients to receive an adequate and effective course
of treatment for gastric ulcer disease leads to recurrence (60-100%) [Sepulveda A.R., Patil
M., 2008]. Currently, gastric and duodenal ulcers are widespread among the population. In
addition, the widespread use of nonsteroidal anti-inflammatory drugs can be considered
another factor. More than 30 million people in the world use nonsteroidal anti
inflammatory drugs (NSAIDs) every day as analgesics, anti-inflammatory and antipyretic
agents. In view of this, the creation of highly effective, economically affordable local drugs
with relatively few side effects is one of the important tasks [Yakubova L.K. et al., 2013;
Usmanova Sh.E., 2017; Dzhanayev G.Yu., Mustanov T.B., 2021].
For this purpose, the anti-ulcer and gastroprotective effects of lesboxol, a complex
preparation consisting of dry extracts of 4 different plants - rough-leaved sedum (Hypericum
scabrum), rosy-leaved sedum (Ziziphora pedicellata), plum tree (Mediasia macrophylla), and
common licorice (Glycyrrhiza glabra), were studied in animals with gastric ulcers under the
influence of a nonsteroidal anti-inflammatory drug.
