EFFECTIVENESS OF A NEW PHYTOPREPARATION IN THE PREVENTION OF GASTRIC ULCER

Abstract

Relevance of the topic: Failure of patients to receive an adequate and effective course of treatment for gastric ulcer disease leads to recurrence (60-100%) [Sepulveda A.R., Patil M., 2008]. Currently, gastric and duodenal ulcers are widespread among the population. In addition, the widespread use of nonsteroidal anti-inflammatory drugs can be considered another factor. More than 30 million people in the world use nonsteroidal anti inflammatory drugs (NSAIDs) every day as analgesics, anti-inflammatory and antipyretic agents. In view of this, the creation of highly effective, economically affordable local drugs with relatively few side effects is one of the important tasks [Yakubova L.K. et al., 2013; Usmanova Sh.E., 2017; Dzhanayev G.Yu., Mustanov T.B., 2021]. For this purpose, the anti-ulcer and gastroprotective effects of lesboxol, a complex preparation consisting of dry extracts of 4 different plants - rough-leaved sedum (Hypericum scabrum), rosy-leaved sedum (Ziziphora pedicellata), plum tree (Mediasia macrophylla), and common licorice (Glycyrrhiza glabra), were studied in animals with gastric ulcers under the influence of a nonsteroidal anti-inflammatory drug.